Assay Detail
Binding
CHEMBL648578
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In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 8.49 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122273 | — | — | 1 | 9.19 |
| CHEMBL338687 | — | — | 1 | 8.96 |
| CHEMBL436396 | — | — | 1 | 8.85 |
| CHEMBL122380 | — | — | 1 | 8.82 |
| CHEMBL125760 | — | — | 1 | 8.82 |
| CHEMBL122157 | — | — | 1 | 8.77 |
| CHEMBL331450 | — | — | 1 | 8.77 |
| CHEMBL435811 | — | — | 1 | 8.74 |
| CHEMBL338888 | — | — | 1 | 8.70 |
| CHEMBL125280 | — | — | 1 | 8.70 |
| CHEMBL122401 | — | — | 1 | 8.70 |
| CHEMBL333224 | — | — | 1 | 8.68 |
| CHEMBL338433 | — | — | 1 | 8.66 |
| CHEMBL341369 | — | — | 1 | 8.66 |
| CHEMBL124771 | — | — | 1 | 8.64 |
| CHEMBL339722 | — | — | 1 | 8.60 |
| CHEMBL121872 | — | — | 1 | 8.60 |
| CHEMBL121907 | — | — | 1 | 8.59 |
| CHEMBL331507 | — | — | 1 | 8.59 |
| CHEMBL331455 | — | — | 1 | 8.57 |
| CHEMBL339113 | — | — | 1 | 8.54 |
| CHEMBL340632 | — | — | 1 | 8.51 |
| CHEMBL339672 | — | — | 1 | 8.51 |
| CHEMBL339040 | — | — | 1 | 8.47 |
| CHEMBL338027 | — | — | 1 | 8.47 |
| CHEMBL339256 | — | — | 1 | 8.46 |
| CHEMBL338889 | — | — | 1 | 8.44 |
| CHEMBL338342 | — | — | 1 | 8.44 |
| CHEMBL339605 | — | — | 1 | 8.43 |
| CHEMBL339806 | — | — | 1 | 8.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122273 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL338687 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL436396 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL122380 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL125760 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL122157 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL331450 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL435811 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL338888 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL125280 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL122401 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL333224 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL341369 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL338433 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL124771 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL339722 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL121872 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL121907 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL331507 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL331455 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL339113 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL340632 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL339672 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL339040 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL338027 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL339256 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL338889 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL338342 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL339605 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL339806 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL339004 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL338434 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL444065 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL273542 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL122917 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL332909 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL332576 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL340078 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL122158 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL334300 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL125008 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL338137 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL421478 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL124903 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL331632 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL276674 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL340473 | — | IC50 | = | 20.0 | nM | 7.70 |