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Compound Detail

CHEMBL332909

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CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL332909
Phase Preclinical
Structure Type MOL
InChI Key QQMNYPQIZBQLSK-UHFFFAOYSA-N
5
Targets
8
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

723.8
MW (Da)
6.72
ALogP
8
HBA
2
HBD
132.2
PSA (Ų)
0.14
QED
2
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C36H33F4N5O5S
MW 723.75
Aromatic Rings 5
Heavy Atoms 51
NP-Likeness -1.41

Activity Summary

IC50 8 meas. best 9.85

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Type-1 angiotensin II receptor
CHEMBL3948
 IC50 9.85 9.85 0.1 3
Angiotensin II receptor (AT-1) type-1
CHEMBL2094250
 IC50 9.82 9.82 0.1 1
Type-1 angiotensin II receptor
CHEMBL227
 IC50 9.49 9.49 0.3 1
Type-2 angiotensin II receptor
CHEMBL257
 IC50 9.29 9.27 0.5 2
Type-2 angiotensin II receptor
CHEMBL4607
 IC50 8.37 8.37 4.3 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Type-1 angiotensin II receptor IC50 = 0.14 nM 9.85 In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit a... 7562905
Type-1 angiotensin II receptor IC50 = 0.1403 nM 9.85 Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor -
Type-1 angiotensin II receptor IC50 = 0.14 nM 9.85 Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor -
Angiotensin II receptor (AT-1) type-1 IC50 = 0.15 nM 9.82 In vitro inhibitory activity against angiotensin II type 1 receptor in rat adren... 7562905
Type-1 angiotensin II receptor IC50 = 0.32 nM 9.49 In vitro inhibitory activity against angiotensin II receptor type 1, in human ad... 7562905
Type-2 angiotensin II receptor IC50 = 0.51 nM 9.29 In vitro inhibitory activity against angiotensin II type 2 receptor in rat adren... 7562905
Type-2 angiotensin II receptor IC50 = 0.56 nM 9.25 In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midb... 7562905
Type-2 angiotensin II receptor IC50 = 4.3 nM 8.37 In vitro inhibitory activity against Angiotensin II receptor type 2 in human adr... 7562905

Literature References

PubMed DOI Target Context # Activities
7562905 10.1021/jm00019a004 Type-2 angiotensin II receptor 3
7562905 10.1021/jm00019a004 Angiotensin II receptor 3
7562905 10.1021/jm00019a004 Type-1 angiotensin II receptor 2
- 10.1007/s00044-011-9815-x Type-1 angiotensin II receptor 2
7562905 10.1021/jm00019a004 Angiotensin II receptor (AT-1) type-1 1

Data from ChEMBL 36 via Core Engine