Assay Detail
Binding
CHEMBL648584
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Alpha-1 adrenergic receptor binding affinity was evaluated by its ability to displace [3H]prazosin in rat brain synaptosomes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Preparation and in vitro biological evaluation of the enantiomers of the diydropyridine BMY 20014, a combination calcium and 1-adrenoreceptor antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.30 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.52 |
| CHEMBL3301661 | — | — | 1 | 8.34 |
| CHEMBL151910 | — | — | 1 | 7.89 |
| CHEMBL2115538 | — | — | 1 | 7.44 |
| CHEMBL2111260 | — | — | 1 | - |
| CHEMBL2111202 | — | — | 1 | - |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL3301661 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL151910 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2115538 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL2111260 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2111202 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL193 | NIFEDIPINE | Ki | > | 1000.0 | nM | - |