Assay Detail
Binding
CHEMBL648585
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro radioligand binding assay on adrenaline Alpha-1 adrenergic receptor of rat cortex using [3H]- prazosin
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Adrenal cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
N-[2-[(substituted chroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylamines: synthesis and wide range of antagonism at the human 5-HT1A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.19 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25213 | — | — | 1 | 8.57 |
| CHEMBL25215 | — | — | 1 | 8.29 |
| CHEMBL278806 | — | — | 1 | 8.06 |
| CHEMBL22682 | — | — | 1 | 7.84 |
| CHEMBL25663 | — | — | 1 | 7.55 |
| CHEMBL21475 | — | — | 1 | 7.46 |
| CHEMBL22328 | — | — | 1 | 7.15 |
| CHEMBL22802 | — | — | 1 | 7.01 |
| CHEMBL38288 | — | — | 1 | 6.05 |
| CHEMBL283968 | — | — | 1 | 5.90 |
| CHEMBL22778 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25213 | — | Ki | = | 2.71 | nM | 8.57 |
| CHEMBL25215 | — | Ki | = | 5.19 | nM | 8.29 |
| CHEMBL278806 | — | Ki | = | 8.77 | nM | 8.06 |
| CHEMBL22682 | — | Ki | = | 14.3 | nM | 7.84 |
| CHEMBL25663 | — | Ki | = | 27.9 | nM | 7.55 |
| CHEMBL21475 | — | Ki | = | 35.1 | nM | 7.46 |
| CHEMBL22328 | — | Ki | = | 71.5 | nM | 7.15 |
| CHEMBL22802 | — | Ki | = | 98.4 | nM | 7.01 |
| CHEMBL38288 | — | Ki | = | 897.0 | nM | 6.05 |
| CHEMBL283968 | — | Ki | = | 1260.0 | nM | 5.90 |
| CHEMBL22778 | — | Ki | = | 6080.0 | nM | 5.22 |