Assay Detail
Binding
CHEMBL648623
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Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.22 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10347 | RAUWOLSCINE | — | 1 | 9.00 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 8.64 |
| CHEMBL3559672 | RAUWOLFIA SERPENTINA | 4.0 | 1 | 8.30 |
| CHEMBL123349 | — | — | 1 | 7.70 |
| CHEMBL25467 | — | — | 1 | 7.68 |
| CHEMBL122404 | AKUAMMIGINE | — | 1 | 7.55 |
| CHEMBL123138 | — | — | 1 | 7.55 |
| CHEMBL123448 | — | — | 1 | 7.46 |
| CHEMBL114166 | — | — | 1 | 7.19 |
| CHEMBL31410 | CORYNANTHEINE | — | 1 | 6.79 |
| CHEMBL279436 | — | — | 1 | 6.78 |
| CHEMBL284103 | — | — | 1 | 6.49 |
| CHEMBL405355 | NIGULDIPINE | 2.0 | 1 | 6.43 |
| CHEMBL3392247 | — | — | 1 | 6.25 |
| CHEMBL5483012 | — | — | 1 | 5.88 |
| CHEMBL3392246 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10347 | RAUWOLSCINE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL15245 | YOHIMBINE | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL3559672 | RAUWOLFIA SERPENTINA | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL123349 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL25467 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL122404 | AKUAMMIGINE | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL123138 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL123448 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL114166 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL31410 | CORYNANTHEINE | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL279436 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL284103 | — | Ki | = | 323.0 | nM | 6.49 |
| CHEMBL405355 | NIGULDIPINE | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL3392247 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL5483012 | — | Ki | = | 1320.0 | nM | 5.88 |
| CHEMBL3392246 | — | Ki | = | 1700.0 | nM | 5.77 |