Assay Detail
Binding
CHEMBL648647
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Binding affinity to rat benzodiazepine receptor
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Identification and structure-activity studies of novel ultrashort-acting benzodiazepine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.19 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL655 | MIDAZOLAM | 4.0 | 1 | 8.70 |
| CHEMBL108819 | — | — | 1 | 8.52 |
| CHEMBL107782 | — | — | 1 | 8.52 |
| CHEMBL108910 | — | — | 1 | 8.52 |
| CHEMBL108991 | — | — | 1 | 8.15 |
| CHEMBL108911 | — | — | 1 | 8.15 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 7.85 |
| CHEMBL107704 | — | — | 1 | 7.77 |
| CHEMBL108233 | — | — | 1 | 7.64 |
| CHEMBL324200 | — | — | 1 | 7.54 |
| CHEMBL321474 | — | — | 1 | 7.47 |
| CHEMBL107506 | — | — | 1 | 7.41 |
| CHEMBL109154 | — | — | 1 | 7.35 |
| CHEMBL327124 | — | — | 1 | 7.28 |
| CHEMBL412571 | — | — | 1 | 7.09 |
| CHEMBL111535 | — | — | 1 | 7.04 |
| CHEMBL321487 | — | — | 1 | 6.93 |
| CHEMBL324194 | — | — | 1 | 6.91 |
| CHEMBL322111 | — | — | 1 | 6.79 |
| CHEMBL109155 | — | — | 1 | 6.75 |
| CHEMBL322930 | — | — | 1 | 6.72 |
| CHEMBL111533 | — | — | 1 | 6.70 |
| CHEMBL111025 | — | — | 1 | 6.62 |
| CHEMBL325801 | — | — | 1 | 6.54 |
| CHEMBL108080 | — | — | 1 | 6.32 |
| CHEMBL108920 | — | — | 1 | 6.13 |
| CHEMBL107816 | — | — | 1 | 5.84 |
| CHEMBL107658 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL655 | MIDAZOLAM | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL108819 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL107782 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL108910 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL108991 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL108911 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL12 | DIAZEPAM | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL107704 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL108233 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL324200 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL321474 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL107506 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL109154 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL327124 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL412571 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL111535 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL321487 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL324194 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL322111 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL109155 | — | Ki | = | 176.0 | nM | 6.75 |
| CHEMBL322930 | — | Ki | = | 189.0 | nM | 6.72 |
| CHEMBL111533 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL111025 | — | Ki | = | 242.0 | nM | 6.62 |
| CHEMBL325801 | — | Ki | = | 289.0 | nM | 6.54 |
| CHEMBL108080 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL108920 | — | Ki | = | 741.0 | nM | 6.13 |
| CHEMBL107816 | — | Ki | = | 1447.0 | nM | 5.84 |
| CHEMBL107658 | — | Ki | = | 100000.0 | nM | 4.00 |