Assay Detail
Binding
CHEMBL648683
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In vitro inhibition of Angiotensin I converting enzyme in Hog plasma
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.48 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 8.92 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 7.60 |
| CHEMBL578 | ENALAPRIL | 4.0 | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL578 | ENALAPRIL | IC50 | = | 1200.0 | nM | 5.92 |