Assay Detail
Binding
CHEMBL648692
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Inhibitory concentration was evaluated by Inhibiting 50% of Angiotensin I converting enzyme activity using 50 uM N-Cbz-Phe-His-Leu as substrate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Exploration of neutral endopeptidase active site by a series of new thiol-containing inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.83 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10247 | THIORPHAN | -1.0 | 1 | 6.85 |
| CHEMBL172978 | — | — | 1 | 6.52 |
| CHEMBL176960 | — | — | 1 | 5.89 |
| CHEMBL367174 | — | — | 1 | 5.55 |
| CHEMBL174066 | — | — | 1 | 5.21 |
| CHEMBL366937 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10247 | THIORPHAN | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL172978 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL176960 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL367174 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL174066 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL366937 | — | IC50 | = | 11000.0 | nM | 4.96 |