Assay Detail
Binding
CHEMBL648703
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Binding affinity against Alpha-2C adrenergic receptor from human clones.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.31 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25554 | — | — | 1 | 9.10 |
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 8.08 |
| CHEMBL114166 | — | — | 1 | 7.19 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 7.02 |
| CHEMBL420060 | — | — | 1 | 6.88 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 6.55 |
| CHEMBL279516 | INDORAMIN | 2.0 | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25554 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL597 | PHENTOLAMINE | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL114166 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL2 | PRAZOSIN | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL420060 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL707 | DOXAZOSIN | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL279516 | INDORAMIN | Ki | = | 476.0 | nM | 6.32 |