Assay Detail
Binding
CHEMBL648714
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Displacement of [3H]RX-821002 from alpha-2 adrenergic receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.50 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6393 | — | — | 1 | 6.29 |
| CHEMBL267399 | — | — | 1 | 5.80 |
| CHEMBL269236 | TRYPTOLINE | — | 1 | 5.80 |
| CHEMBL404505 | — | — | 1 | 5.40 |
| CHEMBL6385 | — | — | 1 | 5.35 |
| CHEMBL269073 | — | — | 1 | 5.02 |
| CHEMBL6503 | — | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6393 | — | Ki | = | 516.0 | nM | 6.29 |
| CHEMBL267399 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL269236 | TRYPTOLINE | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL404505 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL6385 | — | Ki | = | 4510.0 | nM | 5.35 |
| CHEMBL269073 | — | Ki | = | 9550.0 | nM | 5.02 |
| CHEMBL6503 | — | Ki | = | 13400.0 | nM | 4.87 |