Assay Detail
Binding
CHEMBL648715
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Binding affinity towards alpha-2 adrenergic receptor using [3H]rauwolscine as radioligand in competitive binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.42 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86931 | — | — | 1 | 7.40 |
| CHEMBL315468 | — | — | 1 | 6.91 |
| CHEMBL314459 | — | — | 1 | 6.57 |
| CHEMBL82899 | — | — | 1 | 6.35 |
| CHEMBL419680 | — | — | 1 | 5.66 |
| CHEMBL83080 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86931 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL315468 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL314459 | — | Ki | = | 271.0 | nM | 6.57 |
| CHEMBL82899 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL419680 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL83080 | — | Ki | = | 2500.0 | nM | 5.60 |