Assay Detail
Binding
CHEMBL648759
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Cyclopentanespiro-3H-dihydro-pyrimidinones as Angiotensin II AT1 receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.81 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42200 | — | — | 1 | 9.00 |
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | 8.89 |
| CHEMBL40251 | — | — | 1 | 8.66 |
| CHEMBL40250 | — | — | 1 | 7.28 |
| CHEMBL295646 | — | — | 1 | 7.15 |
| CHEMBL295181 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42200 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1513 | IRBESARTAN | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL40251 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL40250 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL295646 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL295181 | — | IC50 | = | 1300.0 | nM | 5.89 |