Assay Detail
Binding
CHEMBL648764
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In vitro binding affinity at Angiotensin II receptor, type 1 from rat liver membrane by [125I]- A II displacement.
17
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Dihydro-imidazolone derivatives as angiotensin II receptor antagonists: chiral effect on the activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.39 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47428 | — | — | 1 | 8.48 |
| CHEMBL47810 | — | — | 3 | 8.34 |
| CHEMBL47669 | — | — | 1 | 8.14 |
| CHEMBL47985 | — | — | 1 | 8.12 |
| CHEMBL296492 | — | — | 1 | 7.92 |
| CHEMBL45485 | — | — | 1 | 7.75 |
| CHEMBL48062 | — | — | 1 | 7.72 |
| CHEMBL290988 | — | — | 1 | 7.46 |
| CHEMBL275437 | — | — | 1 | 7.28 |
| CHEMBL296883 | — | — | 1 | 7.25 |
| CHEMBL44268 | — | — | 1 | 7.10 |
| CHEMBL297250 | — | — | 1 | 6.82 |
| CHEMBL48392 | — | — | 1 | 6.64 |
| CHEMBL46782 | — | — | 1 | 5.77 |
| CHEMBL45493 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47428 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL47810 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL47810 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL47669 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL47985 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL296492 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL45485 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL48062 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL290988 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL275437 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL296883 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL44268 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL47810 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL297250 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL48392 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL46782 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL45493 | — | IC50 | = | 2100.0 | nM | 5.68 |