Assay Detail
Binding
CHEMBL648765
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Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
A potent long-acting imidazole-5-acrylic acid angiotensin II AT-1 receptor antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.67 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317343 | — | — | 1 | 9.80 |
| CHEMBL813 | EPROSARTAN | 4.0 | 1 | 9.00 |
| CHEMBL57309 | — | — | 1 | 8.98 |
| CHEMBL37679 | — | — | 1 | 8.84 |
| CHEMBL97533 | — | — | 1 | 7.93 |
| CHEMBL56574 | — | — | 1 | 7.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317343 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL813 | EPROSARTAN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL57309 | — | IC50 | = | 1.04 | nM | 8.98 |
| CHEMBL37679 | — | IC50 | = | 1.45 | nM | 8.84 |
| CHEMBL97533 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL56574 | — | IC50 | = | 35.4 | nM | 7.45 |