Assay Detail
Binding
CHEMBL648767
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Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranes
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
1,4-substituted indoles: a potent and selective class of angiostensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.34 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4524047 | — | — | 1 | 9.10 |
| CHEMBL2079784 | — | — | 1 | 8.35 |
| CHEMBL2021415 | — | — | 1 | 8.20 |
| CHEMBL1790055 | — | — | 1 | 8.20 |
| CHEMBL2079782 | — | — | 1 | 8.14 |
| CHEMBL2079781 | — | — | 1 | 8.05 |
| CHEMBL2079769 | — | — | 1 | 7.89 |
| CHEMBL2021416 | — | — | 1 | 7.60 |
| CHEMBL2079768 | — | — | 1 | 7.52 |
| CHEMBL2079770 | — | — | 1 | 7.41 |
| CHEMBL288691 | — | — | 1 | 7.10 |
| CHEMBL4524049 | — | — | 1 | 7.10 |
| CHEMBL287065 | — | — | 1 | 6.12 |
| CHEMBL4524048 | — | — | 1 | 6.08 |
| CHEMBL433230 | — | — | 1 | 5.44 |
| CHEMBL36259 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4524047 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL2079784 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL2021415 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL1790055 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL2079782 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL2079781 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL2079769 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2021416 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL2079768 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL2079770 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL288691 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL4524049 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL287065 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL4524048 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL433230 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL36259 | — | Ki | = | 6100.0 | nM | 5.21 |