Assay Detail
Binding
CHEMBL648769
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Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of a novel class of orally active, non-peptide angiotensin II antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.12 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416477 | — | — | 1 | 9.12 |
| CHEMBL421473 | — | — | 1 | 8.56 |
| CHEMBL333534 | — | — | 1 | 8.50 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.83 |
| CHEMBL124772 | — | — | 1 | 7.82 |
| CHEMBL121635 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416477 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL421473 | — | Ki | = | 2.78 | nM | 8.56 |
| CHEMBL333534 | — | Ki | = | 3.13 | nM | 8.50 |
| CHEMBL191 | LOSARTAN | Ki | = | 14.63 | nM | 7.83 |
| CHEMBL124772 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL121635 | — | Ki | = | 122.0 | nM | 6.91 |