Assay Detail
Binding
CHEMBL648770
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Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.55 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | 9.10 |
| CHEMBL126755 | — | — | 1 | 8.33 |
| CHEMBL11706 | BMS-248360 | — | 1 | 8.22 |
| CHEMBL24461 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1513 | IRBESARTAN | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL126755 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL11706 | BMS-248360 | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL24461 | — | Ki | > | 0.0001 | nM | - |