Assay Detail
Binding
CHEMBL648797
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its binding affinity towards Rat-1 cells stably expressing hamster Alpha-1b adrenergic receptor by displacing [125I]HEAT (2-beta-(4-hydroxyphenyl)-ethylaminomethyltetralone)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Cell Type | Rat-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Marine sponge bis(indole) alkaloids that displace ligand binding to 1 adrenergic receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.52 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302882 | — | — | 1 | 7.10 |
| CHEMBL292801 | NORTOPSENTIN B | — | 1 | 6.89 |
| CHEMBL63208 | NORTOPSENTIN C | — | 1 | 6.77 |
| CHEMBL302637 | NORTOPSENTIN A | — | 1 | 6.28 |
| CHEMBL436760 | BROMOTOPSENTIN | — | 1 | 6.13 |
| CHEMBL303282 | TOPSENTIN | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302882 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL292801 | NORTOPSENTIN B | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL63208 | NORTOPSENTIN C | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL302637 | NORTOPSENTIN A | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL436760 | BROMOTOPSENTIN | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL303282 | TOPSENTIN | Ki | = | 1150.0 | nM | 5.94 |