Assay Detail
Binding
CHEMBL648803
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Binding affinity against Adenosine A2 receptor using [3H]NECA with 50 nM CPA in rat striatal brain membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
N6-bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.87 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 6.33 |
| CHEMBL2112184 | — | — | 1 | 6.21 |
| CHEMBL489640 | — | — | 1 | 6.12 |
| CHEMBL2112183 | — | — | 1 | 6.01 |
| CHEMBL2112182 | — | — | 1 | 5.86 |
| CHEMBL477444 | — | — | 1 | 5.73 |
| CHEMBL3038256 | — | — | 1 | 5.68 |
| CHEMBL3038259 | — | — | 1 | 5.52 |
| CHEMBL3038260 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 462.0 | nM | 6.33 |
| CHEMBL2112184 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL489640 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL2112183 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL2112182 | — | Ki | = | 1390.0 | nM | 5.86 |
| CHEMBL477444 | — | Ki | = | 1870.0 | nM | 5.73 |
| CHEMBL3038256 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL3038259 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL3038260 | — | Ki | = | 3900.0 | nM | 5.41 |