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Assay Detail

CHEMBL648819

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity for Alpha-1 adrenergic receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adrenergic receptor alpha-1 (CHEMBL2094251)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.
Mewshaw RE, Husbands M, Gildersleeve ES, Webb MB, Shi X, Mazandarani H, Cockett MI, Ochalski R, Brennan JA, Abou-Gharbia M, Marquis K, McGaughey GB, Coupet J, Andree TH.
Bioorg Med Chem Lett (1998) 8 : 295 -300
PubMed 9871673 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 5.28 5.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL64508 1 5.28
CHEMBL88365 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL64508 Ki = 5291.0 nM 5.28
CHEMBL88365 Ki > 1000.0 nM -