Assay Detail
Binding
CHEMBL648820
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Displacement of [3H]prazosin from Alpha-1 adrenergic receptor
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.93 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166599 | — | — | 2 | 6.37 |
| CHEMBL167004 | — | — | 1 | 6.31 |
| CHEMBL166935 | — | — | 1 | 6.17 |
| CHEMBL169469 | — | — | 1 | 6.14 |
| CHEMBL166697 | — | — | 1 | 6.14 |
| CHEMBL169695 | — | — | 1 | 6.00 |
| CHEMBL166991 | — | — | 1 | 5.92 |
| CHEMBL354482 | — | — | 1 | 5.77 |
| CHEMBL299294 | — | — | 1 | 5.64 |
| CHEMBL168496 | — | — | 1 | 5.50 |
| CHEMBL170552 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166599 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL167004 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL166935 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL169469 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL166697 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL169695 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL166991 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL354482 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL166599 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL299294 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL168496 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL170552 | — | Ki | = | 3300.0 | nM | 5.48 |