Assay Detail
Binding
CHEMBL648824
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Compound was measured in vivo for its binding affinity at Alpha-1 adrenergic receptor using [3H]prazosin as radioligand.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Hindered rotation congeners of mazapertine: High affinity ligands for the 5-HT1A receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.07 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10085 | MAZAPERTINE | 2.0 | 1 | 8.89 |
| CHEMBL61440 | — | — | 1 | 8.77 |
| CHEMBL165364 | — | — | 1 | 8.54 |
| CHEMBL423632 | — | — | 1 | 7.44 |
| CHEMBL164330 | — | — | 1 | 6.70 |
| CHEMBL423642 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10085 | MAZAPERTINE | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL61440 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL165364 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL423632 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL164330 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL423642 | — | Ki | > | 1000.0 | nM | - |