Assay Detail
Binding
CHEMBL648932
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Ability to inhibit Angiotensin I converting enzyme was determined
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Bicyclic lactam inhibitors of angiotensin converting enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.32 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL611148 | — | — | 1 | 8.59 |
| CHEMBL354967 | — | — | 1 | 8.40 |
| CHEMBL434687 | — | — | 1 | 8.05 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 2 | 7.82 |
| CHEMBL355277 | — | — | 1 | 7.28 |
| CHEMBL168520 | — | — | 1 | 6.77 |
| CHEMBL11707 | — | — | 2 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL611148 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL354967 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL434687 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL355277 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL168520 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL11707 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL11707 | — | IC50 | = | 3400.0 | nM | 5.47 |