Assay Detail
Binding
CHEMBL648934
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Concentration required for 50% inhibition of rabbit lung Angiotensin I converting enzyme with 5 mM hippuryl-histidyl-leucine as substrate
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Angiotensin-converting enzyme inhibitors. 2. Perhydroazepin-2-one derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.09 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336822 | — | — | 1 | 8.51 |
| CHEMBL300560 | — | — | 1 | 8.47 |
| CHEMBL335679 | — | — | 1 | 8.44 |
| CHEMBL59172 | — | — | 1 | 8.43 |
| CHEMBL135994 | — | — | 1 | 8.37 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 8.24 |
| CHEMBL135310 | — | — | 1 | 7.79 |
| CHEMBL61439 | — | — | 1 | 7.45 |
| CHEMBL292565 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336822 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL300560 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL335679 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL59172 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL135994 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL135310 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL61439 | — | IC50 | = | 35.5 | nM | 7.45 |
| CHEMBL292565 | — | IC50 | = | 78.2 | nM | 7.11 |