Assay Detail
Binding
CHEMBL648935
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In vitro inhibition of Angiotensin I converting enzyme in rabbit lung
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Lung |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.42 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 8.24 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 7.75 |
| CHEMBL43859 | — | — | 1 | 7.58 |
| CHEMBL578 | ENALAPRIL | 4.0 | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL43859 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL578 | ENALAPRIL | IC50 | = | 800.0 | nM | 6.10 |