Assay Detail
Binding
CHEMBL648942
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat Angiotensin I converting enzyme (ACE), using Hip-Gly-Gly as synthetic substrate.
44
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of potent new angiotensin converting enzyme inhibitors containing saturated bicyclic amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 7.01 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 8.64 |
| CHEMBL3349972 | — | — | 1 | 8.62 |
| CHEMBL2079670 | — | — | 1 | 8.59 |
| CHEMBL416147 | — | — | 1 | 8.49 |
| CHEMBL75752 | — | — | 1 | 8.43 |
| CHEMBL176763 | — | — | 3 | 8.28 |
| CHEMBL369041 | — | — | 2 | 8.19 |
| CHEMBL368598 | — | — | 1 | 8.15 |
| CHEMBL110375 | — | — | 1 | 8.03 |
| CHEMBL360681 | — | — | 1 | 7.96 |
| CHEMBL3351100 | — | — | 3 | 7.96 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 7.92 |
| CHEMBL1744311 | — | — | 1 | 7.89 |
| CHEMBL1744310 | — | — | 1 | 7.85 |
| CHEMBL2052024 | — | — | 1 | 7.75 |
| CHEMBL1744316 | — | — | 1 | 7.62 |
| CHEMBL368775 | — | — | 1 | 7.55 |
| CHEMBL534694 | — | — | 1 | 7.20 |
| CHEMBL558810 | — | — | 3 | 7.10 |
| CHEMBL578 | ENALAPRIL | 4.0 | 1 | 6.85 |
| CHEMBL283586 | — | — | 1 | 6.85 |
| CHEMBL178024 | — | — | 2 | 6.80 |
| CHEMBL1744309 | — | — | 1 | 6.52 |
| CHEMBL541377 | — | — | 1 | 6.47 |
| CHEMBL1794914 | — | — | 1 | 6.38 |
| CHEMBL360469 | — | — | 2 | 6.32 |
| CHEMBL368667 | — | — | 1 | 6.27 |
| CHEMBL1744321 | — | — | 1 | 6.18 |
| CHEMBL10962 | — | — | 1 | 6.09 |
| CHEMBL3085292 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3349972 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL2079670 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL416147 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL75752 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL176763 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL369041 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL368598 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL176763 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL110375 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL3351100 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL360681 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL369041 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1744311 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1744310 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2052024 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1744316 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL368775 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL534694 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL558810 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL578 | ENALAPRIL | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL283586 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL178024 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL558810 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1744309 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL541377 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1794914 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL360469 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL368667 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL360469 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL1744321 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL10962 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL3085292 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL176763 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL178322 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL366957 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3351100 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3351100 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL2093952 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL178024 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL366957 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL368191 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL558810 | — | IC50 | > | 100000.0 | nM | - |