Assay Detail
Binding
CHEMBL648945
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In vitro inhibition of rat angiotensin I converting enzyme
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design of orally active dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme with long duration of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 8.33 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88278 | — | — | 1 | 9.38 |
| CHEMBL86884 | — | — | 1 | 9.34 |
| CHEMBL329125 | — | — | 1 | 9.30 |
| CHEMBL419499 | — | — | 1 | 9.26 |
| CHEMBL313627 | — | — | 1 | 9.22 |
| CHEMBL329823 | — | — | 1 | 9.15 |
| CHEMBL327454 | — | — | 1 | 9.05 |
| CHEMBL86778 | — | — | 1 | 8.82 |
| CHEMBL313764 | — | — | 1 | 8.66 |
| CHEMBL86803 | — | — | 1 | 8.60 |
| CHEMBL86475 | — | — | 1 | 8.51 |
| CHEMBL315601 | — | — | 1 | 8.51 |
| CHEMBL89573 | — | — | 1 | 8.49 |
| CHEMBL89840 | — | — | 1 | 8.46 |
| CHEMBL314215 | — | — | 1 | 8.43 |
| CHEMBL314770 | — | — | 1 | 8.42 |
| CHEMBL90000 | — | — | 1 | 8.38 |
| CHEMBL89695 | — | — | 1 | 8.35 |
| CHEMBL2115220 | — | — | 1 | 8.30 |
| CHEMBL315695 | — | — | 1 | 8.28 |
| CHEMBL427760 | — | — | 1 | 8.21 |
| CHEMBL315037 | — | — | 1 | 8.17 |
| CHEMBL2114220 | — | — | 1 | 7.90 |
| CHEMBL419127 | — | — | 1 | 7.64 |
| CHEMBL87005 | — | — | 1 | 7.60 |
| CHEMBL422417 | — | — | 1 | 7.48 |
| CHEMBL313198 | — | — | 1 | 7.35 |
| CHEMBL89388 | — | — | 1 | 7.32 |
| CHEMBL2114222 | — | — | 1 | 6.95 |
| CHEMBL1160560 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88278 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL86884 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL329125 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL419499 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL313627 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL329823 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL327454 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL86778 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL313764 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL86803 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL86475 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL315601 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL89573 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL89840 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL314215 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL314770 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL90000 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL89695 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL2115220 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL315695 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL427760 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL315037 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL2114220 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL419127 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL87005 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL422417 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL313198 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL89388 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL2114222 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL1160560 | — | IC50 | = | 403.0 | nM | 6.39 |