Assay Detail
Binding
CHEMBL648951
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Inhibitory activity against Angiotensin I converting enzyme (ACE) from rat cortex brain membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Computer-aided selection of potential antihypertensive compounds with dual mechanism of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.25 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL331575 | — | — | 1 | 7.00 |
| CHEMBL322069 | — | — | 1 | 6.00 |
| CHEMBL114552 | — | — | 1 | 4.00 |
| CHEMBL326801 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL331575 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL322069 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL114552 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL326801 | — | IC50 | = | 100000.0 | nM | 4.00 |