Assay Detail
Binding
CHEMBL648955
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Angiotensin II receptor, type 1 in rat liver membrane using [125I]-angiotensin II (0.1 nM)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Development of tetrazole bioisosteres in angiotensin II antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.03 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357878 | — | — | 1 | 9.15 |
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | 8.89 |
| CHEMBL343261 | — | — | 1 | 8.85 |
| CHEMBL148434 | — | — | 1 | 8.77 |
| CHEMBL47810 | — | — | 1 | 8.28 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | — | 1 | 7.85 |
| CHEMBL144089 | — | — | 1 | 7.60 |
| CHEMBL147598 | — | — | 1 | 7.22 |
| CHEMBL148137 | — | — | 1 | 7.00 |
| CHEMBL148379 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357878 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1513 | IRBESARTAN | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL343261 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL148434 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL47810 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL144089 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL147598 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL148137 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL148379 | — | IC50 | = | 230.0 | nM | 6.64 |