Assay Detail
Binding
CHEMBL648958
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Inhibition of [125I]angiotensin II receptor specific binding to rat mesenteric arteries
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Imidazole-5-acrylic acids: potent nonpeptide angiotensin II receptor antagonists designed using a novel peptide pharmacophore model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.85 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127194 | — | — | 1 | 7.05 |
| CHEMBL126921 | — | — | 1 | 6.52 |
| CHEMBL339233 | — | — | 1 | 6.48 |
| CHEMBL340825 | — | — | 1 | 6.40 |
| CHEMBL289543 | — | — | 1 | 6.36 |
| CHEMBL125212 | — | — | 1 | 6.16 |
| CHEMBL124859 | — | — | 1 | 6.14 |
| CHEMBL337928 | — | — | 1 | 5.62 |
| CHEMBL36846 | — | — | 1 | 5.58 |
| CHEMBL432222 | — | — | 1 | 5.52 |
| CHEMBL338813 | — | — | 1 | 5.30 |
| CHEMBL126521 | — | — | 1 | 4.59 |
| CHEMBL25528 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127194 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL126921 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL339233 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL340825 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL289543 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL125212 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL124859 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL337928 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL36846 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL432222 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL338813 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL126521 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL25528 | — | IC50 | = | 43000.0 | nM | 4.37 |