Assay Detail
Binding
CHEMBL648960
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit binding of radioligand [125I]AII to angiotensin II receptor, type 1 in rat adrenal glomerulosa tissue
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Nonpeptide angiotensin II receptor antagonists: synthetic and computational chemistry of N-[[4-[2-(2H-tetrazol-5-yl)-1-cycloalken-1- yl]phenyl]methyl]imidazole derivatives and their in vitro activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.22 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.72 |
| CHEMBL89216 | — | — | 1 | 6.51 |
| CHEMBL314220 | — | — | 1 | 6.41 |
| CHEMBL88350 | — | — | 1 | 6.40 |
| CHEMBL328552 | — | — | 1 | 5.55 |
| CHEMBL314149 | — | — | 1 | 5.50 |
| CHEMBL89403 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191 | LOSARTAN | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL89216 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL314220 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL88350 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL328552 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL314149 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL89403 | — | IC50 | = | 3500.0 | nM | 5.46 |