Assay Detail
Binding
CHEMBL648963
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Inhibition of specific binding of [125I]angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 7.04 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1017 | TELMISARTAN | 4.0 | 1 | 8.52 |
| CHEMBL130095 | — | — | 1 | 8.52 |
| CHEMBL424629 | — | — | 1 | 8.52 |
| CHEMBL130910 | — | — | 1 | 8.52 |
| CHEMBL128922 | — | — | 1 | 8.40 |
| CHEMBL129950 | — | — | 1 | 8.40 |
| CHEMBL337232 | — | — | 1 | 8.30 |
| CHEMBL131767 | — | — | 1 | 8.30 |
| CHEMBL130746 | — | — | 1 | 8.10 |
| CHEMBL132226 | — | — | 1 | 8.00 |
| CHEMBL132282 | — | — | 1 | 7.96 |
| CHEMBL338954 | — | — | 1 | 7.89 |
| CHEMBL337025 | — | — | 1 | 7.68 |
| CHEMBL130741 | — | — | 1 | 7.62 |
| CHEMBL130896 | — | — | 1 | 7.58 |
| CHEMBL131433 | — | — | 1 | 7.58 |
| CHEMBL132280 | — | — | 1 | 7.48 |
| CHEMBL131839 | — | — | 1 | 7.47 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.46 |
| CHEMBL434640 | — | — | 1 | 7.09 |
| CHEMBL128049 | — | — | 1 | 7.07 |
| CHEMBL434815 | — | — | 1 | 6.80 |
| CHEMBL130322 | — | — | 1 | 6.80 |
| CHEMBL131209 | — | — | 1 | 6.80 |
| CHEMBL334515 | — | — | 1 | 6.75 |
| CHEMBL407978 | — | — | 1 | 6.62 |
| CHEMBL274447 | — | — | 1 | 6.46 |
| CHEMBL128340 | — | — | 1 | 6.41 |
| CHEMBL7632 | — | — | 1 | 6.40 |
| CHEMBL131365 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1017 | TELMISARTAN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL130095 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL424629 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL130910 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL128922 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL129950 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL337232 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL131767 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL130746 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL132226 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL132282 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL338954 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL337025 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL130741 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL131433 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL130896 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL132280 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL131839 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL191 | LOSARTAN | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL434640 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL128049 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL434815 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL131209 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL130322 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL334515 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL407978 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL274447 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL128340 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL7632 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL131365 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL131948 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL130828 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL336130 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL128318 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL130600 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL128913 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL130539 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL131722 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL339360 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL335734 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL334741 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL337269 | — | IC50 | = | 29300.0 | nM | 4.53 |