Assay Detail
Binding
CHEMBL648992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for human Alpha-1B adrenergic receptor expressed in COS cell membranes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel arylpiperazines as selective alpha1-adrenergic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.02 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12202 | — | — | 1 | 5.65 |
| CHEMBL12603 | RWJ-68157 | — | 1 | 5.45 |
| CHEMBL12127 | — | — | 1 | 5.27 |
| CHEMBL12501 | — | — | 1 | 5.00 |
| CHEMBL11828 | — | — | 1 | 5.00 |
| CHEMBL418531 | — | — | 1 | 5.00 |
| CHEMBL268030 | — | — | 1 | 5.00 |
| CHEMBL12364 | — | — | 1 | 5.00 |
| CHEMBL12062 | RWJ-69736 | — | 1 | 5.00 |
| CHEMBL274529 | — | — | 1 | 5.00 |
| CHEMBL12529 | — | — | 1 | 4.58 |
| CHEMBL275469 | RWJ-38063 | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12202 | — | Ki | = | 2244.0 | nM | 5.65 |
| CHEMBL12603 | RWJ-68157 | Ki | = | 3536.0 | nM | 5.45 |
| CHEMBL12127 | — | Ki | = | 5316.0 | nM | 5.27 |
| CHEMBL12501 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL11828 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL418531 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL268030 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL12364 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL12062 | RWJ-69736 | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL274529 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL12529 | — | Ki | = | 26310.0 | nM | 4.58 |
| CHEMBL275469 | RWJ-38063 | Ki | = | 46120.0 | nM | 4.34 |