Assay Detail
Binding
CHEMBL648996
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Binding affinity towards human Alpha-1B adrenergic receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.04 | 8.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13735 | — | — | 1 | 8.91 |
| CHEMBL13903 | — | — | 1 | 8.73 |
| CHEMBL13754 | — | — | 1 | 8.43 |
| CHEMBL14213 | — | — | 1 | 8.35 |
| CHEMBL268758 | A-119637 | — | 1 | 8.33 |
| CHEMBL13856 | A-123189 | — | 1 | 8.04 |
| CHEMBL14199 | — | — | 1 | 7.80 |
| CHEMBL13647 | BMY-7378 | — | 1 | 7.03 |
| CHEMBL98241 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13735 | — | Ki | = | 1.22 | nM | 8.91 |
| CHEMBL13903 | — | Ki | = | 1.86 | nM | 8.73 |
| CHEMBL13754 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL14213 | — | Ki | = | 4.47 | nM | 8.35 |
| CHEMBL268758 | A-119637 | Ki | = | 4.66 | nM | 8.33 |
| CHEMBL13856 | A-123189 | Ki | = | 9.09 | nM | 8.04 |
| CHEMBL14199 | — | Ki | = | 15.8 | nM | 7.80 |
| CHEMBL13647 | BMY-7378 | Ki | = | 94.3 | nM | 7.03 |
| CHEMBL98241 | — | Ki | = | 165.0 | nM | 6.78 |