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Assay Detail

CHEMBL649020

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Binding
Inhibitory activity towards Alpha-mannosidase from Jack bean
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Canavalia ensiformis
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Alpha-mannosidase (CHEMBL4193)
Type SINGLE PROTEIN
Organism Glycine max

Publication

Derivatives of (2R,3R,4S)-2-aminomethylpyrrolidine-3,4-diol are selective alpha-mannosidase inhibitors.
Popowycz F, Gerber-Lemaire S, Demange R, Rodriguez-García E, Asenjo AT, Robina I, Vogel P.
Bioorg Med Chem Lett (2001) 11 : 2489 -2493
PubMed 11549453 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.15 4.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL84104 1 4.22
CHEMBL84941 1 4.07
CHEMBL79727 1 -
CHEMBL2206826 1 -
CHEMBL82895 1 -
CHEMBL421340 1 -
CHEMBL84940 1 -
CHEMBL2115197 1 -
CHEMBL309850 1 -
CHEMBL2207397 1 -
CHEMBL2206827 1 -
CHEMBL83278 1 -
CHEMBL84272 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL84104 IC50 = 60000.0 nM 4.22
CHEMBL84941 IC50 = 85000.0 nM 4.07
CHEMBL79727 IC50 = 170000.0 nM -
CHEMBL2206826 IC50 = 300000.0 nM -
CHEMBL82895 IC50 = 700000.0 nM -
CHEMBL421340 IC50 = 440000.0 nM -
CHEMBL84940 IC50 = 560000.0 nM -
CHEMBL2115197 IC50 = 800000.0 nM -
CHEMBL309850 IC50 = 440000.0 nM -
CHEMBL2207397 IC50 = 800000.0 nM -
CHEMBL2206827 IC50 = 490000.0 nM -
CHEMBL83278 IC50 = 180000.0 nM -
CHEMBL84272 IC50 = 700000.0 nM -