Assay Detail
Functional
CHEMBL649031
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration of the drug to reduce cell number to 50% of controls in AuxB1 cell line
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | AuxB1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dicationic bis(9-methylphenazine-1-carboxamides): relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.67 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30232 | — | — | 1 | 9.24 |
| CHEMBL30424 | — | — | 1 | 8.43 |
| CHEMBL31879 | — | — | 1 | 8.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30232 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL30424 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL31879 | — | IC50 | = | 4.5 | nM | 8.35 |