Assay Detail
Binding
CHEMBL649050
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Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Interactions of flavonoids and other phytochemicals with adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.24 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75772 | — | — | 1 | 5.92 |
| CHEMBL147199 | — | — | 1 | 5.86 |
| CHEMBL348436 | CIRSIMARITIN | — | 1 | 5.76 |
| CHEMBL75169 | — | — | 1 | 5.58 |
| CHEMBL309490 | GALANGIN | — | 1 | 5.50 |
| CHEMBL74852 | — | — | 1 | 5.47 |
| CHEMBL356036 | TETRAMETHYLKAEMPFEROL | — | 1 | 5.47 |
| CHEMBL168080 | — | — | 1 | 5.35 |
| CHEMBL148826 | — | — | 1 | 5.17 |
| CHEMBL357089 | — | — | 1 | 4.79 |
| CHEMBL275638 | FLAVONE | 2.0 | 1 | 4.77 |
| CHEMBL149938 | — | — | 1 | 4.76 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.52 |
| CHEMBL337309 | TAXIFOLIN | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75772 | — | Ki | = | 1210.0 | nM | 5.92 |
| CHEMBL147199 | — | Ki | = | 1380.0 | nM | 5.86 |
| CHEMBL348436 | CIRSIMARITIN | Ki | = | 1720.0 | nM | 5.76 |
| CHEMBL75169 | — | Ki | = | 2650.0 | nM | 5.58 |
| CHEMBL309490 | GALANGIN | Ki | = | 3150.0 | nM | 5.50 |
| CHEMBL74852 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL356036 | TETRAMETHYLKAEMPFEROL | Ki | = | 3370.0 | nM | 5.47 |
| CHEMBL168080 | — | Ki | = | 4480.0 | nM | 5.35 |
| CHEMBL148826 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL357089 | — | Ki | = | 16200.0 | nM | 4.79 |
| CHEMBL275638 | FLAVONE | Ki | = | 16900.0 | nM | 4.77 |
| CHEMBL149938 | — | Ki | = | 17500.0 | nM | 4.76 |
| CHEMBL50 | QUERCETIN | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL337309 | TAXIFOLIN | Ki | = | 34100.0 | nM | 4.47 |