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Compound Detail

CHEMBL75772

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COc1cc(OC)c2c(=O)c(OC)c(-c3ccccc3)oc2c1

Basic Information

ChEMBL ID CHEMBL75772
Phase Preclinical
Structure Type MOL
InChI Key CBTHKWVPSIGKMI-UHFFFAOYSA-N
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names

Molecular Properties

312.3
MW (Da)
3.49
ALogP
5
HBA
0
HBD
57.9
PSA (Ų)
0.74
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C18H16O5
MW 312.32
Aromatic Rings 3
Heavy Atoms 23
NP-Likeness 0.81

Activity Summary

Ki 6 meas. best 6.29

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL318
Ki 6.29 6.29 509.0 2
Adenosine receptor A3
CHEMBL256
Ki 5.92 5.92 1210.0 2
Adenosine A2 receptor
CHEMBL2094117
Ki 5.19 5.19 6450.0 1
Adenosine receptor A2a
CHEMBL302
Ki 5.19 5.19 6450.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21493073 10.1016/j.bmc.2011.03.040 3T3-L1 4
9438021 10.1021/jm970446z Adenosine receptor A1 2
9438021 10.1021/jm970446z Adenosine receptor A2a 2
9438021 10.1021/jm970446z Adenosine receptor A3 2
8691424 10.1021/jm950923i Adenosine receptor A1 1
8691424 10.1021/jm950923i Adenosine A2 receptor 1
8691424 10.1021/jm950923i Adenosine receptor A3 1
8691424 10.1021/jm950923i Adenosine receptors; A1 & A3 1
8576921 10.1021/jm950661k Adenosine receptor A1 1
8576921 10.1021/jm950661k Adenosine receptor A2a 1
8576921 10.1021/jm950661k Adenosine receptor A3 1

Data from ChEMBL 36 via Core Engine