Assay Detail
Binding
CHEMBL644774
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Binding affinity at Adenosine A2 receptor in rat striatal membranes by [3H]-CGS- 21680 displacement.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 4.80 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL309490 | GALANGIN | — | 1 | 6.01 |
| CHEMBL76273 | — | — | 1 | 5.49 |
| CHEMBL72862 | — | — | 1 | 5.48 |
| CHEMBL275638 | FLAVONE | 2.0 | 1 | 5.46 |
| CHEMBL75772 | — | — | 1 | 5.19 |
| CHEMBL75590 | — | — | 1 | 4.94 |
| CHEMBL28626 | MORIN | — | 1 | 4.76 |
| CHEMBL75897 | 2'-HYDROXY-FLAVANONE | — | 1 | 4.75 |
| CHEMBL74975 | — | — | 1 | 4.60 |
| CHEMBL74505 | — | — | 1 | 4.57 |
| CHEMBL76874 | — | — | 1 | 4.47 |
| CHEMBL74852 | — | — | 1 | 4.45 |
| CHEMBL45176 | VISNAGIN | — | 1 | 4.37 |
| CHEMBL75169 | — | — | 1 | 4.33 |
| CHEMBL76128 | — | — | 1 | 4.31 |
| CHEMBL309566 | — | — | 1 | 4.26 |
| CHEMBL449090 | — | — | 1 | 4.20 |
| CHEMBL78326 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL309490 | GALANGIN | Ki | = | 966.0 | nM | 6.01 |
| CHEMBL76273 | — | Ki | = | 3220.0 | nM | 5.49 |
| CHEMBL72862 | — | Ki | = | 3310.0 | nM | 5.48 |
| CHEMBL275638 | FLAVONE | Ki | = | 3450.0 | nM | 5.46 |
| CHEMBL75772 | — | Ki | = | 6450.0 | nM | 5.19 |
| CHEMBL75590 | — | Ki | = | 11500.0 | nM | 4.94 |
| CHEMBL28626 | MORIN | Ki | = | 17300.0 | nM | 4.76 |
| CHEMBL75897 | 2'-HYDROXY-FLAVANONE | Ki | = | 17600.0 | nM | 4.75 |
| CHEMBL74975 | — | Ki | = | 25100.0 | nM | 4.60 |
| CHEMBL74505 | — | Ki | = | 26800.0 | nM | 4.57 |
| CHEMBL76874 | — | Ki | = | 33800.0 | nM | 4.47 |
| CHEMBL74852 | — | Ki | = | 35600.0 | nM | 4.45 |
| CHEMBL45176 | VISNAGIN | Ki | = | 42400.0 | nM | 4.37 |
| CHEMBL75169 | — | Ki | = | 46700.0 | nM | 4.33 |
| CHEMBL76128 | — | Ki | = | 49000.0 | nM | 4.31 |
| CHEMBL309566 | — | Ki | = | 54500.0 | nM | 4.26 |
| CHEMBL449090 | — | Ki | = | 63800.0 | nM | 4.20 |
| CHEMBL78326 | — | Ki | = | 167000.0 | nM | - |