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Compound Detail

CHEMBL76128

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CCCOc1c2ccoc2cc2oc(/C=C/c3ccccc3)cc(=O)c12

Basic Information

ChEMBL ID CHEMBL76128
Phase Preclinical
Structure Type MOL
InChI Key RCPBGBWHKGZPFO-CMDGGOBGSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

346.4
MW (Da)
5.50
ALogP
4
HBA
0
HBD
52.6
PSA (Ų)
0.48
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H18O4
MW 346.38
Aromatic Rings 4
Heavy Atoms 26
NP-Likeness 0.73

Activity Summary

Ki 3 meas. best 5.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
Ki 5.4 5.4 3950.0 1
Adenosine receptor A1
CHEMBL318
Ki 4.4 4.4 40000.0 1
Adenosine A2 receptor
CHEMBL2094117
Ki 4.31 4.31 49000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9438021 10.1021/jm970446z Adenosine receptor A1 1
9438021 10.1021/jm970446z Adenosine receptor A2a 1
9438021 10.1021/jm970446z Adenosine receptor A3 1
8691424 10.1021/jm950923i Adenosine receptor A1 1
8691424 10.1021/jm950923i Adenosine A2 receptor 1
8691424 10.1021/jm950923i Adenosine receptor A3 1
8691424 10.1021/jm950923i Adenosine receptors; A1 & A3 1

Data from ChEMBL 36 via Core Engine