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Compound Detail

CHEMBL309566

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O=c1c(Cl)c(-c2ccccc2)oc2ccc(Cl)cc12

Basic Information

ChEMBL ID CHEMBL309566
Phase Preclinical
Structure Type MOL
InChI Key PTNKLWUWHUGKTA-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

291.1
MW (Da)
4.77
ALogP
2
HBA
0
HBD
30.2
PSA (Ų)
0.65
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H8Cl2O2
MW 291.13
Aromatic Rings 3
Heavy Atoms 19
NP-Likeness 0.01

Activity Summary

Ki 2 meas. best 6.13

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
Ki 6.13 6.13 741.0 1
Adenosine A2 receptor
CHEMBL2094117
Ki 4.26 4.26 54500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9438021 10.1021/jm970446z Adenosine receptor A1 1
9438021 10.1021/jm970446z Adenosine receptor A2a 1
9438021 10.1021/jm970446z Adenosine receptor A3 1
8691424 10.1021/jm950923i Adenosine receptor A1 1
8691424 10.1021/jm950923i Adenosine A2 receptor 1
8691424 10.1021/jm950923i Adenosine receptor A3 1
8691424 10.1021/jm950923i Adenosine receptors; A1 & A3 1
469554 10.1021/np50001a002 KB 1

Data from ChEMBL 36 via Core Engine