Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL76874

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CCOc1c2ccoc2cc2oc(/C=C/c3ccccc3)cc(=O)c12

Basic Information

ChEMBL ID CHEMBL76874
Phase Preclinical
Structure Type MOL
InChI Key TZRUAYHMQMKKLT-CMDGGOBGSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

332.4
MW (Da)
5.11
ALogP
4
HBA
0
HBD
52.6
PSA (Ų)
0.52
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H16O4
MW 332.36
Aromatic Rings 4
Heavy Atoms 25
NP-Likeness 0.72

Activity Summary

Ki 4 meas. best 5.94

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
Ki 5.94 5.94 1160.0 1
Adenosine receptor A3
CHEMBL3360
Ki 4.91 4.91 12300.0 1
Adenosine A2 receptor
CHEMBL2094117
Ki 4.47 4.47 33800.0 1
Adenosine receptor A1
CHEMBL318
Ki 4.45 4.45 35600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8691424 10.1021/jm950923i Adenosine receptor A3 2
8691424 10.1021/jm950923i Adenylate cyclase type 2 2
8691424 10.1021/jm950923i Adenosine receptor A1 1
8691424 10.1021/jm950923i Adenosine A2 receptor 1
8691424 10.1021/jm950923i Adenosine receptors; A1 & A3 1
9438021 10.1021/jm970446z Adenosine receptor A1 1
9438021 10.1021/jm970446z Adenosine receptor A2a 1
9438021 10.1021/jm970446z Adenosine receptor A3 1

Data from ChEMBL 36 via Core Engine