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Compound Detail

CHEMBL449090

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CCOc1cc(O)c2c(=O)c(OCC)c(-c3ccccc3)oc2c1

Basic Information

ChEMBL ID CHEMBL449090
Phase Preclinical
Structure Type MOL
InChI Key ZPEWNDIPSPULBP-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

326.4
MW (Da)
3.96
ALogP
5
HBA
1
HBD
68.9
PSA (Ų)
0.77
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H18O5
MW 326.35
Aromatic Rings 3
Heavy Atoms 24
NP-Likeness 0.57

Activity Summary

Ki 3 meas. best 6.13

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
Ki 6.13 6.13 748.0 1
Adenosine receptor A1
CHEMBL318
Ki 5.72 5.72 1890.0 1
Adenosine A2 receptor
CHEMBL2094117
Ki 4.2 4.2 63800.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8691424 10.1021/jm950923i Adenosine receptor A1 1
8691424 10.1021/jm950923i Adenosine A2 receptor 1
8691424 10.1021/jm950923i Adenosine receptor A3 1
8691424 10.1021/jm950923i Adenosine receptors; A1 & A3 1
9438021 10.1021/jm970446z Adenosine receptor A1 1
9438021 10.1021/jm970446z Adenosine receptor A2a 1
9438021 10.1021/jm970446z Adenosine receptor A3 1

Data from ChEMBL 36 via Core Engine