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Compound Detail

CHEMBL72862

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CCOc1cc(OCC)c2c(=O)c(OCC)c(-c3ccccc3)oc2c1

Basic Information

ChEMBL ID CHEMBL72862
Phase Preclinical
Structure Type MOL
InChI Key YMQQPRDUZIXHBJ-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

354.4
MW (Da)
4.66
ALogP
5
HBA
0
HBD
57.9
PSA (Ų)
0.62
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H22O5
MW 354.40
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness 0.24

Activity Summary

Ki 4 meas. best 6.44

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
Ki 6.44 6.44 364.0 1
Adenosine receptor A1
CHEMBL318
Ki 6.22 6.22 603.0 1
Adenosine A2 receptor
CHEMBL2094117
Ki 5.48 5.48 3310.0 1
Adenosine receptor A3
CHEMBL3360
Ki 4.74 4.74 18200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8691424 10.1021/jm950923i Adenosine receptor A3 2
8691424 10.1021/jm950923i Adenylate cyclase type 2 2
8691424 10.1021/jm950923i Adenosine receptor A1 1
8691424 10.1021/jm950923i Adenosine A2 receptor 1
8691424 10.1021/jm950923i Adenosine receptors; A1 & A3 1
9438021 10.1021/jm970446z Adenosine receptor A1 1
9438021 10.1021/jm970446z Adenosine receptor A2a 1
9438021 10.1021/jm970446z Adenosine receptor A3 1

Data from ChEMBL 36 via Core Engine