Assay Detail
Binding
CHEMBL641720
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of specific [3H]PIA binding from adenosine A1 receptor in rat brain membranes.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Interactions of flavonoids and other phytochemicals with adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 5.40 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75772 | — | — | 1 | 6.29 |
| CHEMBL87496 | — | — | 1 | 6.14 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 6.11 |
| CHEMBL309490 | GALANGIN | — | 1 | 6.06 |
| CHEMBL356036 | TETRAMETHYLKAEMPFEROL | — | 1 | 5.97 |
| CHEMBL348436 | CIRSIMARITIN | — | 1 | 5.92 |
| CHEMBL168080 | — | — | 1 | 5.89 |
| CHEMBL293776 | HISPIDULIN | — | 1 | 5.79 |
| CHEMBL16807 | 5-HYDROXYFLAVONE | — | 1 | 5.66 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.61 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | — | 1 | 5.52 |
| CHEMBL28 | APIGENIN | — | 1 | 5.52 |
| CHEMBL351186 | — | — | 1 | 5.51 |
| CHEMBL275638 | FLAVONE | 2.0 | 1 | 5.48 |
| CHEMBL148826 | — | — | 1 | 5.47 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 5.30 |
| CHEMBL351895 | — | — | 1 | 5.26 |
| CHEMBL165387 | — | — | 1 | 5.15 |
| CHEMBL351246 | — | — | 1 | 5.12 |
| CHEMBL74852 | — | — | 1 | 5.09 |
| CHEMBL26260 | BETA-NAPHTHOFLAVONE | — | 1 | 5.06 |
| CHEMBL348920 | — | — | 1 | 5.05 |
| CHEMBL149938 | — | — | 1 | 4.94 |
| CHEMBL349609 | ARBORININE | — | 1 | 4.90 |
| CHEMBL42639 | — | — | 1 | 4.77 |
| CHEMBL345778 | — | — | 1 | 4.73 |
| CHEMBL75169 | — | — | 1 | 4.56 |
| CHEMBL439648 | — | — | 1 | 4.28 |
| CHEMBL147199 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75772 | — | Ki | = | 509.0 | nM | 6.29 |
| CHEMBL87496 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | Ki | = | 786.0 | nM | 6.11 |
| CHEMBL309490 | GALANGIN | Ki | = | 863.0 | nM | 6.06 |
| CHEMBL356036 | TETRAMETHYLKAEMPFEROL | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL348436 | CIRSIMARITIN | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL168080 | — | Ki | = | 1290.0 | nM | 5.89 |
| CHEMBL293776 | HISPIDULIN | Ki | = | 1610.0 | nM | 5.79 |
| CHEMBL16807 | 5-HYDROXYFLAVONE | Ki | = | 2170.0 | nM | 5.66 |
| CHEMBL50 | QUERCETIN | Ki | = | 2470.0 | nM | 5.61 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | Ki | = | 3030.0 | nM | 5.52 |
| CHEMBL28 | APIGENIN | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL351186 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL275638 | FLAVONE | Ki | = | 3280.0 | nM | 5.48 |
| CHEMBL148826 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL44 | GENISTEIN | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL351895 | — | Ki | = | 5550.0 | nM | 5.26 |
| CHEMBL165387 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL351246 | — | Ki | = | 7590.0 | nM | 5.12 |
| CHEMBL74852 | — | Ki | = | 8180.0 | nM | 5.09 |
| CHEMBL26260 | BETA-NAPHTHOFLAVONE | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL348920 | — | Ki | = | 8890.0 | nM | 5.05 |
| CHEMBL149938 | — | Ki | = | 11600.0 | nM | 4.94 |
| CHEMBL349609 | ARBORININE | Ki | = | 12700.0 | nM | 4.90 |
| CHEMBL42639 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL345778 | — | Ki | = | 18800.0 | nM | 4.73 |
| CHEMBL75169 | — | Ki | = | 27600.0 | nM | 4.56 |
| CHEMBL439648 | — | Ki | = | 52500.0 | nM | 4.28 |
| CHEMBL147199 | — | Ki | - | nM | - |