Assay Detail
Binding
CHEMBL649065
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration was evaluated as concentration required to inhibit 50% activity of the rabbit artery Acyl coenzyme A:cholesterol acyltransferase 1
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Acyl-CoA:cholesterol acyltransferase (CHEMBL6141) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.57 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30860 | — | — | 1 | 7.60 |
| CHEMBL33780 | — | — | 1 | 7.40 |
| CHEMBL33661 | — | — | 2 | 6.82 |
| CHEMBL286812 | — | — | 1 | 5.43 |
| CHEMBL289465 | — | — | 2 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30860 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL33780 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL33661 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL33661 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL286812 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL289465 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL289465 | — | IC50 | > | 8500.0 | nM | - |