Assay Detail
Binding
CHEMBL649068
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPCPX from adenosine A1 receptor of rat cortical membranes with GTP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.52 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139835 | CYPROTERONE ACETATE | 3.0 | 1 | 6.90 |
| CHEMBL65976 | — | — | 1 | 4.83 |
| CHEMBL277041 | METHYLTHIOADENOSINE | — | 1 | 4.82 |
| CHEMBL72613 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139835 | CYPROTERONE ACETATE | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL65976 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL277041 | METHYLTHIOADENOSINE | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL72613 | — | IC50 | = | 143000.0 | nM | - |