Assay Detail
Binding
CHEMBL649106
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Ability to displace [3H]DPCPX from Adenosine A1 receptor in rat cortical membrane
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,5'-Disubstituted adenosine derivatives: evaluation of selectivity and efficacy for the adenosine A(1), A(2A), and A(3) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.22 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464859 | NECA | — | 1 | 7.20 |
| CHEMBL2113600 | — | — | 1 | 6.41 |
| CHEMBL610150 | — | — | 1 | 6.15 |
| CHEMBL2113593 | — | — | 1 | 5.98 |
| CHEMBL2113601 | — | — | 1 | 5.90 |
| CHEMBL2113605 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464859 | NECA | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL2113600 | — | Ki | = | 386.0 | nM | 6.41 |
| CHEMBL610150 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL2113593 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL2113601 | — | Ki | = | 1270.0 | nM | 5.90 |
| CHEMBL2113605 | — | Ki | = | 2180.0 | nM | 5.66 |