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Assay Detail

CHEMBL649126

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Potency against PC12 cell A2 adenosine receptor by adenylate cyclase activation
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type PC-12
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adenosine A2 receptor (CHEMBL2094117)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.
Olsson RA, Kusachi S, Thompson RD, Ukena D, Padgett W, Daly JW.
J Med Chem (1986) 29 : 1683 -1689
PubMed 3018244 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 34 5.84 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL261482 1 6.96
CHEMBL464859 NECA 1 6.89
CHEMBL2094086 1 6.55
CHEMBL2094084 1 6.47
CHEMBL603571 1 6.38
CHEMBL606501 1 6.27
CHEMBL519809 1 6.14
CHEMBL2094085 1 6.09
CHEMBL606503 1 6.09
CHEMBL2093998 1 6.01
CHEMBL604834 1 5.92
CHEMBL605449 1 5.92
CHEMBL605863 1 5.85
CHEMBL605866 1 5.81
CHEMBL603990 1 5.75
CHEMBL604207 1 5.74
CHEMBL2093995 1 5.66
CHEMBL606290 1 5.66
CHEMBL2093996 1 5.48
CHEMBL2093997 1 5.44
CHEMBL2094082 1 5.38
CHEMBL603362 1 5.29
CHEMBL606289 1 5.20
CHEMBL605239 1 5.19
CHEMBL603358 1 5.05
CHEMBL605867 1 4.76
CHEMBL604408 1 -
CHEMBL603359 1 -
CHEMBL606285 1 -
CHEMBL606288 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL261482 EC50 = 110.0 nM 6.96
CHEMBL464859 NECA EC50 = 130.0 nM 6.89
CHEMBL2094086 EC50 = 280.0 nM 6.55
CHEMBL2094084 EC50 = 340.0 nM 6.47
CHEMBL603571 EC50 = 420.0 nM 6.38
CHEMBL606501 EC50 = 540.0 nM 6.27
CHEMBL519809 EC50 = 720.0 nM 6.14
CHEMBL2094085 EC50 = 820.0 nM 6.09
CHEMBL606503 EC50 = 820.0 nM 6.09
CHEMBL2093998 EC50 = 980.0 nM 6.01
CHEMBL604834 EC50 = 1200.0 nM 5.92
CHEMBL605449 EC50 = 1200.0 nM 5.92
CHEMBL605863 EC50 = 1400.0 nM 5.85
CHEMBL605866 EC50 = 1560.0 nM 5.81
CHEMBL603990 EC50 = 1800.0 nM 5.75
CHEMBL604207 EC50 = 1830.0 nM 5.74
CHEMBL606290 EC50 = 2200.0 nM 5.66
CHEMBL2093995 EC50 = 2200.0 nM 5.66
CHEMBL2093996 EC50 = 3300.0 nM 5.48
CHEMBL2093997 EC50 = 3600.0 nM 5.44
CHEMBL2094082 EC50 = 4200.0 nM 5.38
CHEMBL603362 EC50 = 5100.0 nM 5.29
CHEMBL606289 EC50 = 6300.0 nM 5.20
CHEMBL605239 EC50 = 6400.0 nM 5.19
CHEMBL603358 EC50 = 8900.0 nM 5.05
CHEMBL605867 EC50 = 17300.0 nM 4.76
CHEMBL604408 EC50 > 100000.0 nM -
CHEMBL603359 EC50 > 100000.0 nM -
CHEMBL606285 EC50 > 100000.0 nM -
CHEMBL606288 EC50 > 30000.0 nM -
CHEMBL606504 EC50 > 100000.0 nM -
CHEMBL605029 EC50 > 100000.0 nM -
CHEMBL603360 EC50 > 100000.0 nM -
CHEMBL603573 EC50 > 100000.0 nM -