Assay Detail
Functional
CHEMBL649127
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Negative chronotropic activity via A2 Adenosine receptor was tested monitoring vasodilation in rat aorta
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Aorta |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 6.47 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113414 | — | — | 1 | 7.23 |
| CHEMBL2113409 | — | — | 1 | 7.16 |
| CHEMBL2113402 | — | — | 1 | 6.96 |
| CHEMBL2094083 | — | — | 1 | 6.91 |
| CHEMBL2113482 | — | — | 1 | 6.85 |
| CHEMBL2113413 | — | — | 1 | 6.52 |
| CHEMBL2113411 | — | — | 1 | 6.48 |
| CHEMBL2113405 | — | — | 1 | 6.47 |
| CHEMBL2113483 | — | — | 1 | 6.43 |
| CHEMBL2113485 | — | — | 1 | 6.42 |
| CHEMBL464859 | NECA | — | 1 | 6.41 |
| CHEMBL2113407 | — | — | 1 | 6.41 |
| CHEMBL2113449 | — | — | 1 | 6.36 |
| CHEMBL2113399 | — | — | 1 | 6.34 |
| CHEMBL2113403 | — | — | 1 | 6.25 |
| CHEMBL410873 | — | — | 1 | 6.22 |
| CHEMBL2113412 | — | — | 1 | 6.15 |
| CHEMBL2113410 | — | — | 1 | 6.08 |
| CHEMBL2113417 | — | — | 1 | 5.92 |
| CHEMBL2113408 | — | — | 1 | 5.78 |
| CHEMBL284969 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113414 | — | EC50 | = | 59.4 | nM | 7.23 |
| CHEMBL2113409 | — | EC50 | = | 69.3 | nM | 7.16 |
| CHEMBL2113402 | — | EC50 | = | 111.0 | nM | 6.96 |
| CHEMBL2094083 | — | EC50 | = | 123.0 | nM | 6.91 |
| CHEMBL2113482 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2113413 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2113411 | — | EC50 | = | 329.0 | nM | 6.48 |
| CHEMBL2113405 | — | EC50 | = | 338.0 | nM | 6.47 |
| CHEMBL2113483 | — | EC50 | = | 367.0 | nM | 6.43 |
| CHEMBL2113485 | — | EC50 | = | 382.0 | nM | 6.42 |
| CHEMBL464859 | NECA | EC50 | = | 394.0 | nM | 6.41 |
| CHEMBL2113407 | — | EC50 | = | 391.0 | nM | 6.41 |
| CHEMBL2113449 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL2113399 | — | EC50 | = | 456.0 | nM | 6.34 |
| CHEMBL2113403 | — | EC50 | = | 564.0 | nM | 6.25 |
| CHEMBL410873 | — | EC50 | = | 596.0 | nM | 6.22 |
| CHEMBL2113412 | — | EC50 | = | 715.0 | nM | 6.15 |
| CHEMBL2113410 | — | EC50 | = | 828.0 | nM | 6.08 |
| CHEMBL2113417 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2113408 | — | EC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL284969 | — | EC50 | > | 10000.0 | nM | - |